Our labs and collaborative publications since 2017.

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Salvatore, M.F., Soto, I., Kasanga, E.A., James, R., Shifflet, M.K., Doshier, K., Little, J.T., John, J., Alphonso, H.M., Cunningham, J.T., Nejtek, V.A.  Establishing equivalent aerobic exercise parameters between early-stage Parkinson's disease and Pink1 knockout rats.  J Parkinson's Dis. 12: 1897-1915, 2022. PMID 35754287

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Salvatore, M.F., Kasanga, E.A., Kelly,P., Venable, K.E. Cantu, M.A., McInnis T.R., Terrebonne, J., Lanza, K., Meadows, S.M., Centner, A., Bishop, C.,  Ingram, D.K. Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake.  GeroScience. 45: 45-63, 2023 PMID 35635679

 

Kasanga, E.A., Little J., McInnis, T.R., Bugnariu, N., Cunningham, J.T., Salvatore, M.F. Cardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats. Front Aging Neurosci 13:775355, 2021. PMID 34975456.

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Nejtek, V.A., James, R.N., Salvatore, M.F., Alphonso, H.M., Boehm, G.W. Premature cognitive decline in specific domains found in young veterans with mTBI coincide with elder normative scores and advanced-age subjects with early-stage Parkinson’s disease. PLoS ONE 16(11):e0258851, 2021. PMID 34788310.

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Salvatore, M.F., Soto, I., Alphonso, H., Cunningham, R., James, R., Nejtek, V.A. Is there a neurobiological rationale for the utility of the Iowa Gambling Task in Parkinson’s Disease?  J Parkinson’s Dis. 11(2): 405-419, 2021. PMID 33361612.

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Kasanga, E.A., Owens, C.L., Cantu, M.A., Richard, A.D., Davis, R.W., McDivitt, L.M., Blancher, B., Pruett, B.S., Tan, C., Gajewski,A., Manfredsson, F.P., Nejtek, V.A., Salvatore, M.F.  GFR-alpha 1 expression in substantia nigra increases bilaterally following unilateral strital GDNF in aged rats and attenuates nigral tyrosine hydroxylase loss following 6-OHDA nigrostriatal lesion.  ACS Chem Neurosci 10: 4237-4249, 2019. PMID: 31538765.

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Churchill, M.J., Cantu, M.A., Kasanga, E.A., Moore, C., Salvatore, M.F., Meshul, C.K.  Glatiramer acetate reverses motor dysfunction and the decrease in tyrosine hydroxylase levels in a mouse model of Parkinson's disease.  Neuroscience 414: 8-27, 2019.  PMID 31220543.

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Salvatore, M.F., McInnis, T.R., Cantu, M.A., Apple, D.M., Pruett, B.S.  Tyrosine hydroxylase inhibition in substantia nigra decreases movement frequency.  Mol Neurobiol 56: 2728-2740, 2019. PMID: 30056575. 

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Salvatore, M.F., Nejtek, V.A., Khoshbouei, H.  Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine.  Neurotoxicology 67: 121-128, 2018.  PMID: 29782882.

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Johnson, M.E., Salvatore, M.F., Maiolo, S.A., Bobrovskaya, L. Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson’s progression: Evidence from clinical studies and neurotoxin models. Prog Neurobiol (review) doi: 10.1016/j.pneurobio.2018.01.002. 2018. PMID: 29331395

 

Arnold, J.C., Cantu, M.A., Kasanga, E.A., Nejtek, V.A., Papa, E.V., Bugnariu, N., Salvatore, M.F. Aging-related limit of exercise efficacy on motor decline. PLoS ONE 12(11): e0188528. 2017. PMID: 29176896.  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188538

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Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine. Kopra J, Villarta-Auuilera M, Savolainen M, Weingeri S, Myöhänen TT, Rannanpää S, Salvatore MF, Andressoo JO, Piepponen TP.  Neuropharmacology 2017 Oct 13 128:221-230.  PMID 29031851  https://www.ncbi.nlm.nih.gov/pubmed/29031851

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Jorge-Finnigan, A., Kleppe, R., Jung-KC, K., Ying, M., Marie, M., Rios-Mondragon, I., Salvatore, M.F., Saraste, J., Martinez, A. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. J Biol Chem 292: 14092-14107, 2017. PMID: 28637871

 

Salvatore, M.F., Terrebonne, J., Cantu, M., McInnis, T., Venable, K., Kelley, P., Kasanga, E., Latimer, B., Owens, C., Pruett, B.S., Yu, Y., Luedtke, R.R., Forster, M.J., Sumien, N., Ingram, D.K. Dissociation of striatal dopamine and tyrosine hydroxylase expression in aging-related motor decline: evidence from calorie restriction intervention. J Gerontol Biol Sci 73: 11-20, 2017. PMID: 28637176

 

Chotibut, T., Meadows, S., Kasanga, E., McInnis, T., Cantu, M.A., Bishop, C., Salvatore, M.F. Ceftriaxone reduces L-DOPA-induced dyskinesia severity in 6-OHDA Parkinson’s disease model. Mov Disord 32: 1547-1556, 2017. PMID: 28631864

 

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