We aim to understand the molecular basis for locomotor impairment in aging and Parkinson's disease. Our immediate and long-term goals are to discover molecular, pharmacological, and non-invasive (exercise, calorie restriction) approaches that can target proteins associated with motor impairment, which can reduce or eliminate locomotor impairment.
Oct 21 2023
Moving Day, Parkinson's Foundation
Moving Day promotes
awareness of the critical
importance to exercise,
and keep busy, in spite of
having Parkinson's. At
Moving Day for DFW was
a very successful event.
The track was filled with
participants with PD,
those caring for one
with PD, and those helping
with providing exercise and other programs. We were delighted to take part with our dog, Lily (who was
very much welcome).
Aug 25 2023
New publication in Experimental Neurology.
Our new study offers insight as to why motor impairment in Parkinson's disease occurs only when the loss of nigrostriatal dopamine neurons is severe. This compensatory process we found occurs in the substantia nigra, not striatum, and gives a possible clue for a therapeutic strategy to improve motor impairment in patients.
Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs
Manuscript to be published in Experimental Neurology
We received notice that our article entitled "DIfferential expression of RET and GDNF family receptor, GFR-a1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling" has been accepted for publication. This study shows that GDNF receptors are diminished in expression as nigrostriatal neuron loss progresses. This finding has direct implications to why GDNF therapy in Parkinson's patients may not have been as effective as anticipated.
Congratulations to Isabel Soto
Senior graduate student Isabel Soto won well-earned recognition for her oral presentation, " Evaluating the Impact of Exercise on UCH-L1, GFAP, and S100B on Early-Stage Parkinson’s Disease: A Translation Study using Pink1-/- and 6-OHDA rats" of her dissertation work on biomarker equivalents in human PD and 2 rat PD models (6-OHDA and Pink1) at the Annual Neurobiology of Aging Symposium held May 9, 2023 at UNTHSC. She was one of 3 students awarded this distinction.
The Salvatore Lab is in its 17th year of pro-active engagement of discovery in neurodegenerative disease and aging-related pathologies that impact the ability to move as desired. Parkinson's disease and aging-related parkinsonism severely compromise this ability. We seek to understand the molecular basis for this impairment in established rodent models and collaborate with those investigating these questions in human studies.
The lab has trained over 3 dozen undergraduate, graduate, and medical students in this process of discovery.